Relationship between levels of Copeptin, NTproBNP and structural functional parameters of the heart in patients with acute myocardial infarction with ST segment elevation complicated by pulmonary hypertension
| Main Authors: | Syvolap, Victor, Zemlianiy, Yaroslav, Brick, Andrey, Bryleva, Vera |
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| Format: | Article |
| Terbitan: |
, 2020
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| Online Access: |
https://zenodo.org/record/3678376 |
Daftar Isi:
- Syvolap Victor, Zemlianiy Yaroslav, Brick Andrey, Bryleva Vera. Relationship between levels of Copeptin, NTproBNP and structural functional parameters of the heart in patients with acute myocardial infarction with ST-segment elevation complicated by pulmonary hypertension. Journal of Education, Health and Sport. 2020;10(2):126-132. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.02.017 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.02.017 https://zenodo.org/record/3678376 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.01.2020. Revised: 25.01.2020. Accepted: 21.02.2020. Relationship between levels of Copeptin, NTproBNP and structural functional parameters of the heart in patients with acute myocardial infarction with ST‐segment elevation complicated by pulmonary hypertension 1Victor D. Syvolap, 1Yaroslav V. Zemlianiy, 2Andrey V. Brick, 2Vera P. Bryleva 1 «Zaporozhye State Medical University» (Ukraine) 2 «City hospital and emergency ambulance" Zaporizhia city council (Ukraine) ABSTRACT Introduction: Acute Myocardial Infarction with ST-Segment Elevation (STEMI) - one of the major causes of morbidity and mortality worldwide, including in Ukraine. The prevalence of pulmonary hypertension (PH) in STEMI significantly is not known due to lack of epidemiological studies in this area. Currently, the prognostic significance of PH in patients with STEMI is not set. Objective: To evaluate the levels of NTproBNP and Copeptin and their relationship with structural and functional features of the heart in patients with STEMI complicated by PH. Materials and Methods: The study involved 85 patients (49 men and 36 women) with STEMI who were treated in intensive care and emergency cardiology for the treatment of patients with myocardial infarction communal non-profit enterprise "City hospital and emergency ambulance" Zaporizhia city council. Patients were divided into two groups: 53 patients with STEMI in the presence of PH (mean age 72,40 ± 2,26 years), 32 patients with STEMI without PH (mean age 67,30 ± 2,12 years). Results: In assessing the clinical anamnesis (Table 1) found that PH mainly develops in the anterior localization of STEMI (73,6%). In patients with STEMI in the presence of PH compared with patients without significant PH frequently observed violations systolic function (64,2%). Significant increasing in the level of copeptin (p <0,05) were found in the serum of patients with acute myocardial infarction in the presence of PH compared with patients with normal pressure in the pulmonary artery (PA). NTproBNP level was also higher in patients with STEMI and PH compared with patients without PH. In patients with STEMI and PH we found reliable positive correlation between the NTproBNP and copeptin level (+0,31; p <0,05), systolic pressure in PA (0,41; p <0,05) and negative correlation between NTproBNP level and ejection fraction (-0,41; p <0,05), stroke volume (-0,42; p <0,05). Copeptin positively correlated with the level of NTproBNP (+0,31; p <0,05), systolic pressure in PA (0,37; p <0,05) and negatively correlated with ejection fraction (-0,30; p <0,05 ). Conclusions: Pulmonary hypertension develops mainly in the anterior localization of STEMI (73,6%) in the presence of systolic dysfunction (64,2%). In patients with STEMI and PH level of NTproBNP and copeptin in serum were increased compared than patients without PH. In patients with STEMI and PH NTproBNP and copeptin levels correlated with decreased left ventricular ejection fraction and increased pressure in the pulmonary artery. Key words: acute myocardial infarction, pulmonary hypertension, copeptin, NTproBNP