Cardiac involvement in children with respiratory chain disorders
| Main Authors: | Josef Finsterer, Claudia Stöllberger |
|---|---|
| Format: | Article |
| Terbitan: |
, 2019
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/3592757 |
Daftar Isi:
- In their article, Yaplito-Lee et al. reported about the cardiac findings in 89 children with mitochondrial disorders (MIDs) [1]. This retrospective study raises some concerns. It would be useful to know if all cardiac investigations applied to assess cardiac involvement (CI) were carried out in each of the 89 patients. We should be informed if focal myositis mentioned in table 2 was attributed to the underlying mitochondrial disorder as MIDs may induce inflammatory reactions [2]. It should be also explained why the “structural heart defect” was not attributed to the underlying disorder. The authors found CI in 29 of 89 patients (33%). However, chest X-ray was carried out only in 58 patients, ECG only in 36 and echocardiography in 36 patients? How can they refer to 89 patients if cardiac investigations were carried out only in a limited number of patients? Were patients included which did not undergo any of these three investigations? It should be indicated how many had X-ray, ECG, or echocardiography alone, and how many underwent combined examinations? Obviously, none of the patients underwent 24h-ambulatory ECG, cardiac MRI, or coronary angiography.