Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations
| Main Authors: | Manzanares-Palenzuela C. Lorena, Pourrahimi Amir M., Gonzalez Julian J., Sofer Zdenek, Pykal Martin, Otyepka Michal, Pumera Martin |
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| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2019
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| Online Access: |
https://zenodo.org/record/3574411 |
Daftar Isi:
- The integration of nucleic acids with nanomaterials has attracted great attention from various research communities in search of new nanoscale tools for a range of applications, from electronics to biomedical uses. MXenes are a new class of multielement 2D materials baring exciting properties mostly directed to energy-related fields. These advanced materials are now beginning to enter the biomedical field given their biocompatibility, hydrophilicity and near-infrared absorption. Herein, we elucidate the interaction of MXene Ti3C2Tx with fluorophore-tagged DNA by fluorescence measurements and molecular dynamics simulations. The system showed potential for biosensing with unequivocal detection at picomole levels and single-base discrimination. We found that this material possesses a kinetically unique entrapment/release behavior, with potential implications in time-controlled biomolecule delivery. Our findings present MXenes as platforms for binding nucleic acids, contributing to their potential for hybridization-based biosensing and related bio-applications.