Effect of Cyp2c19*2 Polymorphism on the Pharmacokinetics of Gliclazide in Healthy Myanmar Volunteers
| Main Authors: | Latt Latt Win, Nang Hla Hla Win, Ne Win, Aye Khine Nyun, Swe Setk |
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| Format: | Article |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3541535 |
Daftar Isi:
- This study aimed to determine the effect of CYP2C19*2 polymorphism on the pharmacokinetics of gliclazide in healthy Myanmar volunteers. In the phase I study, a total of 150 subjects, of either sex of different ethnicities, were randomly selected for determination of CYP2C19 genotype. Among them, 53.3% were normal/wild type, 40% were heterozygous and 6.67% were homozygous for CYP2C19*2 genotype. In the phase II study, one tablet of Reclide containing 80 mg of gliclazide was given to each volunteer and blood samples were collected at 0, 1, 2, 3, 4, 5, 6, 8, 10 and 24 hr after drug administration. Plasma gliclazide concentrations were determined by validated HPLC method and the pharmacokinetic parameters were compared among three different genotypes.