Computing patient-specific hemodynamics in stented femoral artery models obtained from computed tomography using a validated 3D reconstruction method
| Main Authors: | Colombo, Monika, Bologna, Marco, Garbey, Marc, Berceli, Scott, He, Yong, Rodriguez Matas, Josè Felix, Migliavacca, Francesco, Chiastra, Claudio |
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| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3527704 |
Daftar Isi:
- Patients with peripheral artery disease who undergo endovascular treatment are often inflicted by in-stent restenosis. The relation between restenosis and abnormal hemodynamics may be analyzed using patient-specific computational fluid dynamics (CFD) simulations. In this work, first a three-dimensional (3D) reconstruction method, based on an in-house semi-automatic segmentation algorithm of a patient’s computed tomography (CT) images with calcification and metallic artifacts, and thrombus removal is de- scribed. The reconstruction method was validated using 3D printed rigid phantoms of stented femoral arteries by comparing the reconstructed geometries with the reference computer-aided design (CAD) ge- ometries employed for 3D printing. The mean reconstruction error resulting from the validation of the re- construction method was ~6% in both stented and non-stented regions. Secondly, a patient-specific model of the stented femoral artery was created and CFD analyses were performed with emphasis on the se- lection of the boundary conditions. CFD results were compared in scenarios with and without common femoral artery bifurcation, employing flat or parabolic inlet velocity profiles. Similar helical flow struc- tures were visible in all scenarios. Negligible differences in wall shear stress (< 0.5%) were found in the stented region. In conclusion, a robust method, applicable to patient-specific cases of stented diseased femoral arteries, was developed and validated.
- This work has been supported by Fondazione Cariplo, Italy (Grant number 2017-0792, TIME).