Catalase restores the altered mRNA expression of collagen and matrix metalloproteinases by dermal fibroblasts exposed to reactive oxygen species
| Main Authors: | Zaw KK, Yokoyama Y, Abe M, Ishikawa O |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2006
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| Online Access: |
https://zenodo.org/record/3478843 |
Daftar Isi:
- We investigated the effects of reactive oxygen species (ROS) on mRNA expression of proalphal (l) collagen, proalphal (lll) collagen, matrix metalloproteinases-1 (MMP-1), 72 kDa type lV collagenase (MMP-2), and tissue inhibitor of metalloproteinase (TIMP-1) by normal human dermal fibroblasts in a novel three-dimensional culture. Fibroblasts exposed to ROS generated by the hypoxanthine-xanthine oxidase system revealed an increased mRNAexpression of MMP-1 and MMP-2 with a maximum at48 h and 72h after exposure. A slight increase in the mRNA level of tissue inhibitor of metalloproteinase (TIMP-1) was observed.