Peculiarities of the formation of polyorganic dysfunction syndrome in experimental abdominal sepsis: kidney dysfunction
| Main Authors: | Sydorchuk, Ruslan, Stepan, Vasyl, Plehutsa, Oleksandr, Sydorchuk, Igor, Stepan, Bogdan |
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| Format: | Article |
| Terbitan: |
, 2018
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| Online Access: |
https://zenodo.org/record/3463504 |
Daftar Isi:
- Sydorchuk Ruslan, Stepan Vasyl, Plehutsa Oleksandr, Sydorchuk Igor, Stepan Bogdan. Peculiarities of the formation of polyorganic dysfunction syndrome in experimental abdominal sepsis: kidney dysfunction. Journal of Education, Health and Sport. 2018;8(11):863-869. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3463504 http://ojs.ukw.edu.pl/index.php/johs/article/view/7545 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author(s) 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 19.11.2018. Revised: 22.11.2018. Accepted: 30.11.2018. PECULIARITIES OF THE FORMATION OF POLYORGANIC DYSFUNCTION SYNDROME IN EXPERIMENTAL ABDOMINAL SEPSIS: KIDNEY DYSFUNCTION Ruslan Sydorchuk1, Vasyl Stepan2, Oleksandr Plehutsa3, Igor Sydorchuk4, Bogdan Stepan5 1General Surgery Department, HSEE of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine; rsydorchuk@ukr.net; ORCID: 0000-0002-3603-3432; 2Urology Department, HSEE of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine; swt-chern@ukr.net; ORCID: 0000-0001-5733-9871; 3Surgery Department, Acute an Emergency Hospital, Chernivtsi, Ukraine; plehutsa@ukr.net; ORCID: 0000-0002-8639-1262; 4Microbiology Department, HSEE of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine; elvirasydorchuk@gmail.com; ORCID: 0000-0002-9494-1041; 5Surgery Department, Wolyn Regional Hospital, Lutsk, Ukraine; swt-chern@ukr.net; ORCID: 0000-0002-4899-808X; Corresponding author: Vasyl Stepan Address: Theatre Sq., 2, 58003 Chernivtsi, Poland +38 050 6763283; swt-chern@ukr.net. Acknowledgments The result of the present study does not constitute an endorsement of the product by the authors or the journal. Conflict of interest The authors declare that they have no conflict of interest. Abstract Introduction: A steady increase in the incidence of the abdominal sepsis puts it into the top priority in terms of both medical and socio-economic significance. Multiple organ failure/dysfunction syndrome is one of the most important components of the pathogenesis of abdominal sepsis, determining the severity of the course, features of the clinical picture, mortality and outcome. The aim of the study is to determine the dynamics of changes in the functional state of the excretory system under the conditions of modeling of the AS in the acute experiment. Material and methods: The study included acute experiment on 38 white rats with abdominal sepsis modeled by intraabdominal injection of a patented mixture of both aerobic and anaerobic conditionally pathogenic microorganisms' suspension and adjuvant substances influencing local host resistance. This study conforms to international and national standards of bioethics. Kidneys' functional state was evaluated by determining a set of 46 functional markers. Results: All renal function parameters were significantly influenced by abdominal sepsis formation. At the beginning of the formation of the abdominal sepsis, the disruption of the transport of sodium ions is concentrated mainly in the area of the distal tubules. Subsequently, the zone of functional disorders also covers the proximal nephron. Conclusions: Formation of abdominal sepsis is characterized by a complex of physiological changes in the functional state of the kidneys, both adaptive- compensatory and pathological. Renal function undergoes phase changes under abdominal sepsis with predominantly adaptive and compensatory mechanisms dominating at the beginning with further involvement of kidneys' components and formation of renal dysfunction. Keywords: kidney, physiology, pathology, abdominal sepsis.