Extended Beta-Lactamase (ESBL) Producing Salmonella typhi from Presumptive Typhoid Patients in Nasarawa State, Nigeria
| Main Authors: | LAMINI, Jebes Ngolo, NFONGEH, Joseph Fur, OROLE, Olukayode Olugbenga |
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| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3406351 |
Daftar Isi:
- This study was designed to determine the prevalence and antibiogram profile of extended spectrum β-lactamase producing Salmonella typhi from stool samples of symptomatic and asymptomatic typhoid patients from three selected hospitals in Nasarawa State, Nigeria. Four hundred and fifty stool samples were collected from hospitals in Doma, Lafia and Obi and isolation done using standard culture and serological techniques. Double disc diffusion technique was employed to determine isolates’ capacity to produce β-lactamase and antibiogram profile carried out. Results showed that 76(28.00%) of the samples collected were positive for Salmonella species. Prevalence of S. typhi in symptomatic patients was 13.77%, while asymptomatic patients had 5.33%, and a significant difference with a p value of 0.129 obtained between symptomatic and asymptomatic patients. Prevalence of S. typhi in symptomatic patients with regard to sex showed that male patients were more susceptible to the isolates in Doma and Obi with values of 8(11.43%) and 11(15.28%) respectively, while female had 7(5.26%) and 7(5.60%) in Doma and Obi respectively. Patients aged between 18-29 years recorded 27(6.00%) prevalence rate as the highest, while age group 66-77 recorded 5(1.11%) prevalence throughout the duration of study. Isolates with the capacity of producing β-lactamase enzymes were 5(1.11%) in symptomatic patients and 1(0.22%) in asymptomatic patients. Antibiogram profile showed that ESBL-producers were sensitive to Augmentin and imipenem at 100%, while non ESBL-producers were sensitive to Augmentin at 100%, ceftriaxone at 85.86% and 100% resistant to imipenem and ampicillin. The study concluded that beta-lactamases with the capacity of conferring multidrug resistance were found in Salmonella typhi species isolated from willing patients in hospitals in Nasarawa State, Nigeria.