Adiponectin as novel key player in tumors of adrenal glands – what do we know? A review
| Main Authors: | Szydełko, Joanna, Litwińczuk, Michał, Szydełko, Magdalena, Matyjaszek-Matuszek, Beata |
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| Format: | Article |
| Terbitan: |
, 2019
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| Online Access: |
https://zenodo.org/record/3398869 |
Daftar Isi:
- Szydełko Joanna, Litwińczuk Michał, Szydełko Magdalena, Matyjaszek-Matuszek Beata. Adiponectin as novel key player in tumors of adrenal glands – what do we know? A review. Journal of Education, Health and Sport. 2019;9(9):228-246. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3398869 http://ojs.ukw.edu.pl/index.php/johs/article/view/7389 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.08.2019. Revised: 30.08.2019. Accepted: 05.09.2019. Adiponectin as novel key player in tumors of adrenal glands – what do we know? A review Joanna Szydełko1a, Michał Litwińczuk1b, Magdalena Szydełko2c, Beata Matyjaszek-Matuszek1d 1Department of Endocrinology, Medical University of Lublin, Poland 2Medical Student, I Faculty of Medicine with Dentistry Division, Medical University of Lublin, Poland a jszydelko@interia.pl, ORCID ID: https://orcid.org/0000-0003-3744-9058 b mlitwinczuk405@gmail.com, ORCID ID: https://orcid.org/0000-0002-4086-6779 c mszydelko@interia.pl, ORCID ID: https://orcid.org/0000-0001-6216-9934 d bmm@2com.pl, ORCID ID: https://orcid.org/0000-0001-7386-8087 Corresponding author: Joanna Szydełko Department of Endocrinology Jaczewskiego 8 Street 20-954 Lublin, Poland phone: +48 81 72 44 668 e-mail: jszydelko@interia.pl Abstract Introduction: Adrenal incidentalomas without clinically apparent hormonal activities have becoming a huge socio-economic problem due to recent advances in radiological techniques. Patients with incidentalomas are considered to be at high risk of developing metabolic disorders and cardiovascular diseases. That is why, the two-way relationship between adipose tissue activity and adrenal glands is in high interest and an object of extensively studies. Aim of the study: This article summarizes the current knowledge about adiponectin and its receptors in the tumorigenesis of adrenal neoplasia as well as their role in the developing obesity-related diseases. Description of knowledge: Adiponectin, an adipose tissue-derived pleiotropic hormone, with anti-inflammatory, anti-atherogenic, anti-diabetic, and insulin-sensitizing properties is engaged in developing diabetes mellitus type 2, hypertension or ischemic heart disease, but the latest researches also revealed its role in tumor cells proliferation and angiogenesis. The possible effects of adiponectin and its two receptors in both physiological processes and pathophysiology of adrenal glands is not fully understood. Recent studies suggested that adiponectin receptors expression is significantly higher in hormonally active adrenal tumors as compared to normal tissues of adrenal glands, which may prove the involving of adipose tissue and periadrenal fat depot in regulating the function of adrenal cortex or medulla. Conclusions: Adiponectin may be predictive factor of developing metabolic disorders in the group of patients with accidentally detected adrenal lesions. The discovering of its exact mechanism may result in modifying novel screening options as well as diagnostic process and treatment scheme. Therefore, further research is required to determine the effect of adiponectin and its role in the pathogenesis of obesity-related diseases in the course of adrenal tumors. Key words: adiponectin, incidentaloma, adrenal glands, metabolic disorders