Gut microbiota and autism
| Main Authors: | Boreński, Grzegorz, Wójcik, Magdalena, Poleszak, Julita, Szabat, Przemysław, Szabat, Marta, Milanowska, Joanna |
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| Format: | Article |
| Terbitan: |
, 2019
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| Online Access: |
https://zenodo.org/record/3395320 |
Daftar Isi:
- Boreński Grzegorz, Wójcik Magdalena, Poleszak Julita, Szabat Przemysław, Szabat Marta, Milanowska Joanna. Gut microbiota and autism. Journal of Education, Health and Sport. 2019;9(9):204-212. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3395320 http://ojs.ukw.edu.pl/index.php/johs/article/view/7380 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.08.2019. Revised: 30.08.2019. Accepted: 05.09.2019. Gut microbiota and autism Grzegorz Boreński1*, Magdalena Wójcik1, Julita Poleszak1, Przemysław Szabat1, Marta Szabat1, Joanna Milanowska2 (1) Student Science Club at the Department of Applied Psychology, Medical University of Lublin (2) Department of Applied Psychology, Medical University of Lublin * E-mail address: grzegorz.borenski@gmail.com ORCID ID: Grzegorz Boreński https://orcid.org/0000-0002-5359-7555 Magdalena Wójcik https://orcid.org/0000-0002-0999-6284 Julita Poleszak https://orcid.org/0000-0002-5166-6262 Marta Szabat https://orcid.org/0000-0001-6309-2027 Przemysław Szabat https://orcid.org/0000-0001-5796-1900 Joanna Milanowska https://orcid.org/0000-0001-9741-1583 Abstract Introduction: Autism spectrum disorders (ASD) constitutes a group of brain developmental disorders and is characterized by difficulty with social communication and restricted, repetitive patterns of behavior, interest, or activities. ASD has no clear etiology and research is still ongoing to find it. Gut microbiota seems to have significant impact on the development of autism. The aim of the study: The purpose of this systemic review was to collect and analyse available data about the role of gut microbiota and new methods of treatment of ASD. Material and method: Standard criteria were used to review the literature data. The search of articles in the PubMed and Google Scholar database was carried out using the following keywords: autism spectrum disorder, gut microbiota, probiotics. Description of the state of knowledge: In the studies we can found that symptoms from gastrointestinal tract occur more often in patients with ASD. Many studies confirm alterations in gut microbiota accompanying autism. The general changes are imbalance between Bacteroidetes and Firmicutes phyla, increased population of Sutterella and higher level of cultured Clostridium species in the feces. Researchers try to find a reason of these microbiota changes and the main cause they indicate is using antibiotics. Restoration of microbial balance in the colon, for instance by probiotics or microbiota transfer therapy may have beneficial effect on treatment of ASD. Summary: Complicated relationship between gut microbiota and brain needs more studies, but at that point we can find its association with autism and ASD and also with anorexia nervosa, depression and other mood disorders and GI diseases. Among currently available methods of treatment we can distinguish behavioural treatment, pharmacological approach (risperidone and aripiprazole) and complementary and alternative medicine therapies. Understanding the impact of microbiota on autism opens up new paths of treatment, for instance probiotics, fecal microbiota transplantation or microbiota transfer therapy. Although, there is a great need for more researches of their efficacy. Key words: autism spectrum disorder, gut microbiota, probiotics