Role of Cannabinoids for Reluctant Epilepsy
| Main Author: | Dr. Hoori Shahwar, Dr Saera Qedwai , Professor Shaukat Ali |
|---|---|
| Format: | Article |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3386321 |
Daftar Isi:
- Records of cannabis usage for medicinal purposes can be traced back to as early6 as during the 1800 BCE Sumerian context. While similar records of cannabis usage in medicinal purpose exist in other contexts as well, legislations coming up with the development of Phenobarbital in 1912 and Phenytoin in 1937 resulted in gradual decrease in the use of medicinal cannabis. Epilepsy as a refractory disease while been attempted to treat using anti-seizure drugs for at least the last twenty years has not been largely effective in realizing positive outcomes. The utility of cannabis as an alternative treatment for epileptic seizures without the associated side effects of seizure control drugs to the CNS has been focusing upon once again as pieces of evidence have been provided by scholarly research and empirical studies regarding the efficiency exhibited by cannabis in seizure control in children with severe epilepsy. This paper adopted a method of systematic review of scholarly literature and research evidences from various publication sources focusing in the endocannabinoid system, comparing animal models of seizure and epilepsy and evidences of treatment of epilepsy in human using cannabinoids. The historical case of Charlotte Figi, suffering from prolonged status epilepticus Since 3 months of age was also referred to as one of the most significant evidences of the efficacy of cannabinoids in treatment of epilepsy.