Purification and activity analysis of GS loop mutations of ALK2 (ACVR1)
| Main Authors: | Williams, E. P., Bullock, A.N. |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2019
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/3364406 |
Daftar Isi:
- Purification of GS loop mutant constructs of the kinase/gs loop region of ALK2 (ACVR1) and subsequent analysis of activity by mass spec to look at the impact that these mutations have on the overall activity of the protein to help identify the specific functions of the phosphorylation sites. You can read more about it on open note books.
- Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.