Inflammation-induced formation of fat-associated lymphoid clusters
| Main Authors: | Cécile Bénézech, Nguyet-Thin Luu, Jennifer A. Walker, Andrei A. Kruglov, Yunhua Loo, Kyoko Nakamura, Yang Zhang, Saba Nayar, Lucy H. Jones, Adriana Flores-Langarica, Alistair McIntosh, Jennifer Marshall, Francesca Barone, Gurdyal Besra, Katherine Miles, Judith E. Allen, Mohini Gray, George Kollias, Adam F. Cunningham, David R. Withers, Kai Michael Toellner, Nick D. Jones, Marc Veldhoen, Sergei A. Nedospasov, Andrew N.J. McKenzie, Jorge H. Caamaño1 |
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| Format: | Article Journal |
| Terbitan: |
, 2017
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| Online Access: |
https://zenodo.org/record/291418 |
Daftar Isi:
- Fat-associated lymphoid clusters (FALCs) are a recently discovered type of lymphoid tissue associated with visceral fat. Here we show that distribution of FALCs was heterogeneous with the pericardium containing large numbers of these clusters. FALCs contributed to the retention of B-1 B cells in the peritoneal cavity through high expression of the chemokine CXCL13 and supported B cell proliferation and germinal center differentiation during peritoneal immune challenges. FALC formation was induced by inflammation, which triggered recruitment of myeloid cells that express tumor necrosis factor (TNF) necessary for TNF receptor-signaling in stromal cells. CD1drestricted Natural killer T (NKT) cells were likewise required for inducible formation of FALCs. Thus, FALCs support and coordinate innate B and T cell activation during serosal immune responses.