COMPARATIVE STUDY ON CONVENTIONAL, MICROWAVE AND ULTRASOUND-ASSISTED SYNTHESIS AND BIOLOGICAL EVALUATION OF TETRAZOLE DERIVATIVES
| Main Author: | Mohite P.B. 1 *, Bhoge N.D 2 |
|---|---|
| Format: | Article |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/2647848 |
Daftar Isi:
- ABSTRACT In the present study a series of novel 6-(4-nitrophenyl)-4-substituted-3-(1H-tetrazol-5-yl)pyridin-2(1H)-one derivatives(3a-3j) by conventional, microwave and ultrasound assisted synthesis method. Advantages of the ultra sound effect were observed and high yields of the products were obtained after20–45 min ultrasonication. Characterization and structural elucidation of the products was realized based on chemical, analytical and spectral analyses. The results clearly demonstrated a high efficiency of the ultrasonic systems was achieved in the chemical processes. New compound were screened for anti-microbial evaluation. The results revealed that many of the synthesized 6-(4-nitrophenyl)-4-substituted-3-(1H-tetrazol-5-yl)pyridin-2(1H)-one derivatives has good anti-microbial activity. KEYWORDS: Chalcones, Tetrazole, Pyridin-2(1H)-one, Anti-microbial activity.