RehabMove 2018: THE INFLAMMATORY RESPONSE TO EXERCISE IN SPINAL CORD INJURED INDIVIDUALS – THE INFLUENCE OF AUTONOMIC FUNCTION
| Main Authors: | Hoekstra, S.P., Leicht, C.A., Kamijo, Y.I., Kinoshita, T., Stephenson, B.T., Goosey-Tolfrey, V.L., Bishop, N.C., Tajima, F. |
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| Format: | Proceeding |
| Bahasa: | eng |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/2606720 |
Daftar Isi:
- The acute inflammatory response to exercise is attenuated in individuals with a cervical spinal cord injury (SCI), possibly related to the autonomic dysfunction resulting in the impaired sympathetic innervation below the lesion. Purpose This study investigates the influence of autonomic function on the acute inflammatory response to endurance exercise in people with SCI using exercise-induced as well as resting measures of autonomic function. Methods Seventeen wheelchair athletes with a cervical SCI (CSCI, N=7) and without a cervical SCI (NON-CSCI, N=10) participated in a wheelchair half-marathon. Blood was taken prior, post and 1 h post-race to determine serum concentrations of adrenaline and noradrenaline as measures of autonomic function and interleukin-6 (IL-6) as a measure of the inflammatory response to exercise. Supine blood pressure and heart rate variability were measured to assess autonomic function at rest. Results CSCI showed a lower ratio of the low and high frequency power of the variability in RR intervals (LF/HF RRI, p=0.038) and low frequency power of the systolic blood pressure variability (LF SBP, p=0.005) compared to NON-CSCI. Following the race, catecholamine concentrations increased only in NON-CSCI (p<0.036). The increase in IL-6 post-race was larger in NON-CSCI (p=0.040). Post-race catecholamine levels explained 60% of the variance in the IL-6 response (r=0.77, p=0.040), which was further increased when LF/HF RRI and LF SBP were added to the regression model (R2=81%, p=0.012). Conclusion Post-exercise plasma catecholamine concentrations and the autonomic function measures at rest revealed impaired autonomic function in CSCI, which was strongly associated with the attenuated IL-6 response to exercise in this group. Therefore, the autonomic dysfunction present in individuals with a cervical SCI may make exercise less effective in preventing chronic low-grade inflammation in this population.