Repeat proteins as versatile scaffolds for arrays of redox-active FeS clusters
| Main Authors: | Mejias, SH, Bahrami-Dizicheh, Z, Liutkus, M, Sommer, DJ, Astashkin, A, Kodis, G, Ghirlanda, G, Cortajarena, AL. |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2019
|
| Online Access: |
https://zenodo.org/record/2594513 |
Daftar Isi:
- Arrays of one, two and four electron-transfer active [4Fe–4S] clusters were constructed on modular tetratricopeptide repeat protein scaffolds, with the number of clusters determined solely by the size of the scaffold. The constructs show reversible redox activity and transient charge stabilization necessary to facilitate charge transfer.
- This work has been supported by the European Research Council ERC-2014-CoG-648071-ProNANO (ALC), the Spanish Ministry of Economy and Competitiveness (MINECO) BIO2016-77367-C2-1-R (ALC), the Basque Government Elkartek KK-2017/00008 and the National Science Foundation (CHE-CLP award SusChEM 1508301). This work was performed under the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency – Grant No. MDM-2017-0720. SHM thanks the Basque Government for financial support through a PhD fellowship.