INTERLEUKIN-6(IL-6) GENE POLYMORPHISMS ASSOCIATED WITH TYPE 2 DIABETES MELLITUS IN KERALA POPULATION
| Main Authors: | Ashif CM, Balasubramanian T, Pawan Kumar, FasaluRahiman OM |
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| Format: | Article Journal |
| Terbitan: |
, 2017
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/259357 |
Daftar Isi:
- Inflammatory mechanisms play a key role in the pathogenesis of type 2 diabetes. Individuals who progress to type 2diabetes display features of low grade inflammation years in advance of disease onset. Interleukin-6 is a proinflammatory cytokine. Therefore, A population-based study was undertaken to evaluate whether the promoter polymorphisms of interleukin 6 (IL-6; C-174G) genes predict the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in the Kerala population. DNA was isolated from venous blood samples of T2DM patients (n=150) and normal healthy controls (n=150). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed after biochemical analysis. The genotypic and allelic frequency distributions were analyzed. The clinical/biochemical parameters of T2DM cases when compared to controls showed a significant difference. Significant association was observed with -174 G/C (P<0.001). Our data suggest that IL-6 gene polymorphisms play a prominent role in T2DM disease susceptibility in population from South Kerala.