DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
| Main Authors: | Buzov, Andrey, Kulikov, Alexandr, Avtina, Tatyana, Pokrovskii, Mikhail, Osipova, Ol'ga |
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| Format: | Article |
| Terbitan: |
Pensoft Publishers
, 2016
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/2534742 |
Daftar Isi:
- We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation No MD-4711.2015.7 and МК-6135.2016.4.