STUDYING DOSE-DEPENDENT ENDOTHELIO- AND CARDIOPROTECTIVE ACTIVITY OF SELECTIVE ARGINASE II INHIBITOR IN HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION
| Main Authors: | Yakushev, Vladimir, Filippenko, Nikolaj, Kizilova, Irina, Korokin, Mikhail, Beskhmelnitsyna, Evgeniya, Litvinova, Anna |
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| Format: | Article |
| Terbitan: |
Pensoft Publishers
, 2016
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/2534738 |
Daftar Isi:
- This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The results of the studies prove the presence in the arginase II selective inhibitor, the substance under the code ZB49-0010C, dosedependent endothelioprotective and cardioprotective activity, which expression increases with the increase in dose and is maximum at a dose of 10 mg/kg. The research was partially supported by the grant of the President of the Russian Federation NoMD-4711.2015.7.