Comparison of Topological, Physiochemical and Hydrophobic Parameters for QSAR Study on Flavonoid Derivatives as Tyrosins Kinase Inhibitors
| Main Authors: | Kapil Tiwari, Pramod K Saxena, Brij K Tiwari |
|---|---|
| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/2528775 |
Daftar Isi:
- QSAR studies on a large set of fiavonoids derivatives as tyrosine kinase inhibitators have been preformed using 3D-topological, physiological parameters. Activity analysed in the present study in the log1/(inverse logarithmic value of 50% inhibitory concentration). The tyrosine kinase inhibition activity is usually expressed in terms of inverse logarithmic concentration. The set of 104 fiavonoid derivatives is divided in three different sets based on nature of substitution types of substitution and activity shown by the compounds.