A NOVEL SERIES SYNTHESIS OF 2-SUBSTITUTEDIMINO-6-ETHYLAMINO-4-[2-ISOBUTOXY-5(4-METHYL-5-CARBOXY-1,3-THIAZO-2-YL)]-PHENYL-1,3,5-THIADIAZINES
| Main Authors: | D.T.Tayade, A.S.Shendge, P.R.Kale |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/200329 |
Daftar Isi:
- A simple, novel and suitable method has been developed for the synthesis of 2-substitutedimino-6-ethylamino-4-[2-isobutoxy-5(4-methyl-5-carboxy-1,3-thiazo-2-yl)]-phenyl-1,3,5-thiadiazines (VIIIa-h) by the reaction of 2-(3-phenylthioamidoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazole (IIIb) and various dichloroisothiocyanate (VIIa-h) in 60% ethanol-acetone at 1:1 molar proportion for 2 hours. The method provides rapid and easy access to compounds in good yields by using 60% ethanol-acetone medium. The structures of all the synthesized compounds were justified on the basis of chemical characteristics, elemental analysis and spectral studies.