Imaging of histamine receptors by means of PET and SPECT
| Main Authors: | Funke, Uta, Vugts, Danielle J, Janssen, Bieneke, Spaans, Arnold, Kruijer, Perry S, Lammertsma, Adriaan A, Perk, Lars R, Windhorst, Albert D |
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| Format: | Book publication-section Journal |
| Terbitan: |
Springer-Verlag Berlin Heidelberg
, 2014
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| Online Access: |
https://zenodo.org/record/14868 |
Daftar Isi:
- The histaminergic system contains four subtypes of G-protein-coupled receptors:H1 R, H2 R, H3 R and H4 R. In the central nervous system, they mediate the action of histamine in pituitary hormone secretion, wakefulness, motor and cognitive functions as well as in itch and nociception. Alterations in the cerebral histaminergic neurotransmission are associated with numerous neurological diseases, e.g. sleep/wake and eating disorders, epilepsy, neuropathic pain, neurodegeneration and neuroinfl ammation. Therefore, histamine receptors are a target of high interest, not only for therapy, but also for imaging and quantifi cation using PET and SPECT. In addition to indirect fl ow and metabolism studies, this chapter provides a review of results of preclinical and clinical investigations with subtype-selective tracers.