MONONUCLEAR COPPER, NICKEL AND ZINC COMPLEXES POSSESSING BIO-POTENTIAL LIGAND PINOCEMBRIN: SYNTHESIS, CHARACTERIZATION AND DNA BINDING CLEAVAGE STUDIES
| Main Author: | S. Iyyam Pillai*, C. Joel, K. VIjayaraghavan and S. Subramanian |
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| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1470661 |
Daftar Isi:
- Flavonoids are widely occurring polyphenol compounds of plant origin with multiple biological and chemical activities. DNA binding studies of flavonoids are needed to understand the reaction mechanism and improve drugs that target DNA. Due to the presence of carbonyl and hydroxyl groups they can coordinate metal ions and form complexes. Pinocembrin is a natural flavonoid compound which is capable of antioxidant, antibacterial, anti-inflammatory, and antineoplastic activities. Present research work reports the new metal [Cu(II), Ni(II) and Zn(II)] complexes of Pinocembrin. Their structural features and other properties has been characterized by FT-IR and Mass spectral analysis. Interactions of the synthesized complexes towards calf thymus-DNA were determined by emission, absorption, circular dichroism, and viscosity techniques. Detailed investigation reveals that these complexes bind with DNA via intercalation binding. The present effort shows the potential of spectroscopic analysis to characterize the nature of drug–metal complex and the effects of such interaction on the structure of biomolecule. Key words: Flavonoid, Pinocembrin, DNA binding, Intercalation, DNA–drug interaction