RCT RESEATCH STUDY FOR CURING HEPATIC ENCEPHALOPATHY AND ITS COMPARISON WITH LACTULOSE ONLY TREATMENT, THE EVALUATION OF USEFULNESS, FOR TREATMENT OF HEPATIC ENCEPHALOPATHY
| Main Author: | Dr. Shaneela Sattar, Kashifa BB, Dr. Muhammad |
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| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1461052 |
Daftar Isi:
- Objective: Research was held for the evaluation of usefulness, for treatment of hepatic encephalopathy by means of lactulose and rifaximin combination therapy and its comparison with lactulose only treatment in adult patients. Study Design: Randomized Controlled Trial (RCT). Place and Duration of Study: Current research study was held for the period of 7 months from October, 2017 to April, 2018 at Services Hospital, Lahore. Method: With the help of WHO calculator 130 patients were selected for the research purpose. Equally divided the patients into two groups as the strength of each group was 65. One group was medicated with 550mg of lactulose and rifaximin twice in a day and the second group was given 30ml of lactulose three times in a day for the duration of ten days. From patients and their guardians took an informed written consent. Definition of grade two to four hepatic encephalopathy was done through West-Haven Classification method. After starting the treatment patients were observed for ten days. Results: Amongst the selected patients 53.08% were men and 46.92% were women with average age of 55.95 ± 10 years. After observation of ten days, 67.68% patients were found with positive recovery who were medicated with rifaximin and lactulose. On the other hand, the patients who were treated with lactulose only resulted 58.45% recovery. Resulted P-value was 0.276 that was totally not significant statistically. Conclusion: Our research concludes that no prescribable difference was found in effectiveness of treatment with lactulose and rifaximin combination as compared to lactulose only medical treatment in patients with grade two to four hepatic encephalopathy. Key words: Chronic liver disease (CLD), Hepatic encephalopathy, Lactulose, Rifaximin.