UTILIZATION PATTERN OF NSAIDs; A PROSPECTIVE ANALYSIS OF PATIENTS IN A TRAUMA CARE CENTRE
| Main Author: | Niby 1*, Elna Paul 1, Jeethu k shaji ,Lalitha S , Sivakumar T |
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| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1451476 |
Daftar Isi:
- Background and purpose:. NSAIDs are commonly used for managing mild to moderate pain while in most trauma patients injuries are too severe to be relieved by NSAIDs alone .NSAIDs are the most used and abused drugs in the world today.Therefore, the aim of this study was to analyze the drug utilization pattern of NSAIDs in a trauma care centre. Objectives: To evaluate the number of patients exposed to specified NSAIDs within a given time period, estimate (e.g. on the basis data on a disease) to what extent NSAIDs are properly used, overused or underused. Determine the pattern or profile of NSAID use and the extent to which alternative NSAIDs are being used to treat particular conditions. Methodology: A prospective observational study on drug utilization and prescribing pattern of NSAIDs in a trauma care Centre was carried out for a period of 6 months and 1200 prescriptions of different condition were randomly selected. Data were analyzed using descriptive statistics and the results were presented by using frequency distribution table with Microsoft excel .Results: The most common indication for NSAIDs in our study was Fractures (41.58%), Arthritis (16.91), Spine disorders (13.41%), Crush injuries (7.16%), ACL tears (2.55%) and others (18.41%). The present study shows that acetaminophen (97.75%) was the most frequently used non-opioid analgesic followed by Non-selective COX-inhibitors (71.41%) and preferential COX-2 inhibitors (55.75%). The duration of administration ranged from 5-15 days (mean 5.95 days) which conformed to the standard practice. About 4.08% patients took Acetaminophen more than 4g/ day according to this survey and that shows overdose of acetaminophen. Conclusion: Our study has shown that NSAIDs continue to be the drug of choice as analgesics & anti-inflammatory agents for fractures & degenerative joint diseases in this trauma care center. Non- selective COX inhibitors are preferred over the preferential COX 2 Inhibitors. Exclusion of selective cox-2 inhibitors can be seen. Acetaminophen is a viable alternative to the NSAIDs, High prevalence of GPAs co-prescription was noted here as non-selective NSAIDs prescribed according to the standard guidelines. Keywords: NSAIDs, drug utilization, COX-inhibitors, Acetaminophen.