Comparative genomics and phylogenetic study of Plasmodium falciparum and Plasmodium vivax
| Main Authors: | Manoj Kumar Yadav, Alok Mishra, D. Swati |
|---|---|
| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2010
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1438322 |
Daftar Isi:
- Abstract Malaria is a lethal human disease in terms of morbidity and mortality and is caused by Plasmodium species. Main obstacle in conquering this disease is their rapidly evolving genetic structure. Recently published whole genome of Plasmodium vivax provides an opportunity to compare it in depth with the previously published genome of Plasmodium falciparum. Here we have compared each and every chromosome of both the species and found the surprising presence of an unknown bases N. By analyzing tandem repeats it was clear that its copy number is always high in case of P.falciparum and it has strong correlation with their chromosome length. All the vir and var genes are also analyzed and very little sequence homology found between them. In order to find the functional role of vir and var gene protein products, amino acid composition is analyzed. The frequency of hydrophilic amino acids is found more in comparison with the hydrophobic one. Phylogenetic analysis of mitochondrial cytochrome b and nuclear encoded High mobility group binding (HMGB) proteins was done. On the basis of phylogeny result of HMGB it was found that this transcription factor can act as a reference point for the development of separate drugs for P.falciparum and P. vivax and this strategy is supposed to be more reliable in the eradication of malaria. Key words: Allelic diversity, phylogeny, tandem repeats, vertical transfer, invasiveness http://www.ijbst.org/Home/papers-published/ijbst-2010-volume-3-issue-4