EVALUATION OF ACUTE AND CHRONIC ANTI-INFLAMMATORY ACTIVITY IN ETHANOLIC EXTRACT OF AERIAL PARTS OF CARDIOSPERMUM HALICACABUM AND CARDIOSPERMUM CANESCENS IN ANIMAL MODELS
| Main Author: | Kudaravalli Sreedevi 1 *, Jangala Venkateswara Rao 2 |
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| Format: | Article |
| Terbitan: |
, 2017
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1419589 |
Daftar Isi:
- ABSTRACT The present study investigates the zcute and chronic anti-inflammatory activity in ethanolic extract of aerial parts of Cardiospermum halicacabum and Cardiospermum canescens L using carrageenan, Acetic acid, Xylene , PMA induced edema in animals significantly swelling inhibited ***P<0.001 when compared to control group P<0.001when compared to test ethanolic extract dose 250mg, 500mgP<0.001 when compared to stabdard drug.And inchronic inflammatory study revealed that treatment of rats with both the extracts of Cardiospermum halicacabum and Cardiospermum canescens (250 mg/kg and 500 mg/kg) showed significant (P<0.001) reduction in weight of cotton pellet induced granuloma, Formalin induced edema in mice with 500 mg/kg of both extracts significantly (P<0.001) reduced paw thickness whereas 250 mg/kg of both extracts showed lesser effect (P<0.01) in reducing the paw volume. KEYWORDS: Cardiospermum halicacabum and Cardiospermum canescens ethanolic extract, Indomethacin, Anti-inflammatory activity, Carrageenan, Indomethacin, Acetic acid, Xylene, PMA, Formalin, Cotton pellets.