EFFECTS OF COMBINATION THERAPY OF ESCITALOPRAM AND L-METHYLFOLATE IN COMPARISON TO USAGE OF MONOTHERAPY
| Main Author: | Muhammad Muneeb Amjad, Awais Ahmed, Shumaila Qasim |
|---|---|
| Format: | Article |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1401461 |
Daftar Isi:
- Objective: Our objective in this research was the assessment and evaluation of L-Methyl folate efficacy in the combine form along with the escitalopram in comparison to the escitalopram monotherapy in the depression. Place and Duration of Study: The study was carried out from Jan, 18 to Jun, 18 in 6 months at Mayo Hospital Lahore. Material and Methods: The number of patients was 260 which were having Major Depression’s primary diagnosis along with score above fourteen on depression (Hamilton rating scale) i.e. HAM-D & they were selected in this study of Randomized Controlled Trial. The patients were classified in two groups & then Group-A was given ten milligram (Escitalopram) in addition to placebo while group B was given ten milligram (Escitalopram) in addition to L-Methyl folate in the form of a dose of 15 mg. Group-A and Group-B were assessed again after 1 month & the scores of HAM-D were measured. Results: In the total number of 260 patients, the response was there in 70.8 percent i.e. 184 & 29.2 percent i.e. 76 never responded to the treatment. The patients were 82 at 63.1 percent which have shown response to treatment but 48 patients at 36.9 percent never responded and these patients were total 130 which were treated along with SSRI. In total 130 patients which were treated with escitalopram & L-Methyl folate, 28 at 21.5 percent never responded and 102 at 78.5 percent showed response to treatment. With a confidence interval of 95 percent, the P-value was observed as (0.006) which showed that primary difference of both interventions was statistically significant. Conclusion: Our final result was that a combination of L-Methyl folate & SSRI in depression may prove to be more efficient as compared to the Escitalopram monotherapy. Keywords: Major depressive disorder, Escitalopram, L-Methyl folate.