EFFICACY OF TERLIPRESSIN IN CASES PRESENTING WITH UPPER GI BLEED DUE TO DECOMPENSATED LIVER CIRRHOSIS
| Main Author: | Shaista Ghaffar, Asad Nawaz, Zainab Iqbal |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1336294 |
Daftar Isi:
- Objective; To determine the efficacy of Terlipressin in cases presenting with upper GI bleed due to decompensated liver cirrhosis. Methodology: This was a cases series study conducted at LGH, Lahore during January to July 2017. In this study the cases of Decompensated liver cirrhosis of both genders and in adult range of age more than 18 years were included. Decompensated liver cirrhosis was labelled by the presence of liver size less than 12 cm, coarse echo texture and with any of the following i.e. ascites, portal vein dilatation more than 1 cm, spider angioma, gastric varices or caput medusa. The cases with upper GI bleed of any amount were included. the cases with NSAIDs use and those with any renal or heart failure were excluded. Then injection Terlipressin was administered in a dose of 1 mg intravenous every six hour and they were followed for another 24 hour. Efficacy was labeled as yes where there was no bleeding after 24 hours of Terlipressin administration. Results: In this study there were total 100 cases of decompensated liver cirrhosis presented with upper GI bleed out of which 57 (57%) were males and 43 (43%) were females. The mean age at presentation was 57.21±8.23 years. Efficacy of Terlipressin in such cases was seen in 57 (57%) of the cases. The efficacy was near significant high in cases that had duration of cirrhosis more than 3 years where it was observed in 38 (64.4%) of cases with p=0.09. Efficacy of Terlipressin was more in cases with child Pugh class B reflecting in 48 (65.75%) of cases with significant p value of 0.03. Conclusion; Terlipressin has shown good efficacy in Upper GI bleed and it is significantly high in cases that had child pugh class B. Key words: Cirrhosis, Upper GI bleed, Terlipressin