PERINATAL OUTCOME IN PRE ECLAMPTIC FEMALES WITH AND WITHOUT HYPERURICEMIA
| Main Author: | Dr. Nida Pervaiz, Dr. Amir Hussain, Dr. Aamna Shahbaz |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1319071 |
Daftar Isi:
- Aim: To compare perinatal outcome in pre eclamptic females with and without hyperuricemia Methods: 120 cases (60 in two groups) between 28-32 weeks of gestation, 20-40 years of age, diagnosed women with pre-eclampsia with singleton pregnancy were enrolled. We excluded all those cases with chronic renal disease, essential hypertension, diabetes mellitus, gout and those already under treatment of hyperuricemia. This study was conducted at Department of Obstet & Gynaecology, Civil Hospital Karachi in the duration of 6 months from July 2017 to December 2017. Two groups were formed, in study group all those cases with increased level of serum uric acid (> 5.5mg / dl at term) and control group (no increase in serum uric acid level), all these cases were admitted in hospital and followed till delivery following all ethical issues. Close monitoring was done during their stay at hospital and managed according in case of any complication developed during this period. All these cases were followed till delivery of the fetus. The presence of neonatal complications i.e. IUD’s or IUGR were diagnosed on ultra-sonographic examination. Results: Out of 120 cases (60 in each group), mean age in study group was 28.67+4.16 years and 29.96+3.68 yeas in control group. Comparison of perinatal outcome shows that 73.33%(n=44) in study group and 38.33%(n=23) in control group had IUGR, p value was 0.0001 whereas IUD was recorded in 31.67%(n=19) in study group and 6.67%(n=4) in control group, p value was 0.0005. Conclusion: Adverse perinatal outcome i.e. IUGR and IUD is significantly higher in pre-eclamptic females with hyperuricemia as compared to those without elevated levels of serum uric acid Keywords: Pre-eclampsia, elevated levels of serum uric acid, adverse perinatal outcome