FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ALBENDAZOLE
| Main Author: | *Ramachandra M. Koli, Ritesh S. Bathe, Rupali V. Hirave, Santosh S. Ghutukade, Gosavi Rohit S, Bharat B.Garande |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1318585 |
Daftar Isi:
- Albendazole is an oral broad spectrum anthelmintic, antiparasitic agent generally prescribed for the treatment of tissue infections caused by a variety of namatodes, Threadworm, Hookworm, and Tapeworm. It has low bioavailability due to its first pass metabolism. It is water insoluble drug. The purpose of the present research work was to formulate and evaluate the mouth dissolving tablets of Albendazole by direct compression method using different superdisintegrants like sodium starch glycolate, croscarmellose sodium, and crospovidone in different concentrations. FT-IR spectroscopy was used to investigate the physical characteristics of the complex. The blend was evaluated for angle of repose, bulk density, tapped density, Carr’s index hausner’s ratio. The tablet were evaluated for hardness, weight variation, friability, disintegration time, water absorption ratio, wetting time, drug content uniformity and in-vitro dissolution. The % cumulative release of drug from tablet (F5) was found to be more than 97.06% within 40 minutes. It was concluded from the study that Albendazole may improve patient compliance especially pediatric and geriatric patients and increase the efficacy of drug for treating infections. Keywords: Albendazole, Mouth dissolving tablets, Superdisintegrants.