FORMULATION AND INVITRO EVALUATION OF RIZATRIPTAN ORAL THIN FILMS
| Main Author: | Perumalla Ashok Kumar 1 *, Dr. Deenanath Jhade 2 |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1318318 |
Daftar Isi:
- ABSTRACT In present study oral thin films of Rizatriptan was developed to have a faster on set of action. The oral thin films were developed by using polymers HPMC E5, HPMC E 15 and PVP K90.Oral thin films were prepared by employing solvent casting method. Propylene glycol was selected as permeation enhancer and plasticizer. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F12, and all the formulations were evaluated for various physical parameters Physical appearance, Weight variation, Thickness, Folding endurance, Tensile strength, Drug content, Moisture uptake, Moisture content and all the results were found to be were found to be with in the pharmacopeial limits. Among all the 9 formulations of Rizatriptan F3 formulation which contains HPMC E15 150 mg showed 98.76% cumulative drug release within 30 min by performing dissolution test. Compared to HPMC E15, HPMC E5 and PVP K90, HPMC E 15 showed better drug release profile. Hence it was considered as optimized formulation. KEYWORDS: Rizatriptan, HPMC E15, HPMC E5, PVP K90 and HPMC E 15.