ФУНКЦІОНУВАННЯ СИСТЕМИ NO В СИРОВАТЦІ КРОВІ І СЛИЗОВІЙ ОБОЛОНЦІ ШЛУНКУ ЩУРІВ ЗА УМОВ ТРИВАЛОЇ ГІПОАЦИДНОСТІ ШЛУНКОВОГО СОКУ ТА ЗАСТОСУВАННЯ МУЛЬТИПРОБІОТИКІВ
| Main Authors: | С.В. Пилипенко, А.А. Коваль, А.Г. Бажан |
|---|---|
| Format: | Article Journal |
| Bahasa: | ukr |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1318207 |
Daftar Isi:
- In conditions of dysbacteriosis of the stomach caused by the 28-day administration of omeprazole, the production of NO in the blood serum and gastric mucosa increases. To eliminate dysbacteriosis, we proposed the use of the multiprobiotics «Symbiter» and «Apibakt» and directed the studies to determine the content of nitrite ions (NO2ˉ) in the studied media of rats with prolonged gastric juice hypoacidity caused by omeprazole under the conditions of administration of omeprazole and the mentioned multiprobiotics. As a result of our studies, we found that during the 28-day introduction of omeprazole with the multiprobitic «Symbiter» or with the multiprobiotic «Apibakt» the content of nitrite ions in the serum was not statistically significantly different from the control. In gastric mucosa, the multiprobiotics «Symbier» and «Apibakt» that are approximately the same decreased the content of nitrite ions by 24,9% (p <0,05) and 20,2% (p<0,05) respectively, compared to the group of rats, which for 28 days were administered only omeprazole. At the same time, the content of nitrite ions in the mucous membrane of the stomach of rats remained quite high in comparison with the control by 83,9% (p<0,05) and 95,4% (p<0,05) respectively. The data obtained correlated with changes in the activity of nitric oxide synthase (NOS). After simultaneous administration of omeprazole and multiprobiotic «Symbiter», as well as omeprazole and multipibiotic «Apibakt», NOS activity decreased by 16,3% (p<0,05) and 14,4% (p<0,05) respectively. As with the content of nitrite ions, NOS activity did not return to control values and remained higher by 106,5% (p<0,05) and 111,3% (p<0,05) respectively, compared with the control. Thus, the probable multiprobiotics «Symbier» and «Apibakt» had the greatest influence on the content of nitrite ions in the blood serum, which decreased to the control parameters. In the gastric mucosa, multiprobiotics, which eliminated dysbacteriosis, reduced, but did not restore the content of nitrate ions to the level of control.