RADIATION INDUCED OXIDATIVE STRESS IN LIVER AND ITS MITIGATION BY CHLOROPHYTUM BORIVILIANUM ROOT EXTRACT: IN VIVO STUDY
| Main Author: | Sanjay Singh |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1313984 |
Daftar Isi:
- In this study, protective effects of C. borivilianum root extract (CBE) against radiation-induced oxidative stress have been investigated in liver of Swiss albino mice. Adult mice selected from an inbred colony were administered with CBE (50 mg/kg body wt) for 7 days prior to treatment with 6 Gy Co60 γ-radiations. After irradiation, mice were sacrificed at different time intervals (i.e. day 1, 7, 15 and 30) to determine the alterations due to irradiation in hepatic lipid peroxidation (LPO), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and total protein contents and its probable amelioration by CBE. We found that, pretreatment of CBE significantly restored GSH (p<0.01), CAT (p<0.01), SOD (p<0.05) and total protein content (p<0.05) in liver and precluded from radiation induced augmentation in lipid peroxidation (p<0.01). In conclusion, it can be said that C. borivilianum root extract plays a significant role in radioprotection.