The influence of genetic factors on the pathogenesis of hypertrophic scars and keloids
| Main Authors: | Liberski, Sławomir, Marczak, Daria, Migdalski, Arkadiusz |
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| Format: | Article Journal |
| Terbitan: |
, 2018
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| Online Access: |
https://zenodo.org/record/1310110 |
Daftar Isi:
- Liberski Sławomir, Marczak Daria, Migdalski Arkadiusz. The influence of genetic factors on the pathogenesis of hypertrophic scars and keloids. Journal of Education, Health and Sport. 2018;8(8):313-321. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1310110 http://ojs.ukw.edu.pl/index.php/johs/article/view/5645 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.06.2018. Revised: 28.06.2018. Accepted: 12.07.2018. The influence of genetic factors on the pathogenesis of hypertrophic scars and keloids Sławomir Liberski1, liberski@o2.pl ORCID: https://orcid.org/0000-0002-6942-2506 Daria Marczak1, dariamarczak1@wp.pl ORCID: https://orcid.org/0000-0003-2404-8001 Arkadiusz Migdalski2, armigos@wp.pl ORCID: https://orcid.org/0000-0002-9835-5103 1 Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland 2Department of Vascular Surgery and Angiology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090Bydgoszcz, Poland Abstract: Hypertrophic scars and keloids are forms of abnormal scarring, which may be the cause of somatic ailmants and, due to unfavorable aesthetic effect, also mental disorders and social problems. Given the unclear aetiology and the lack of effective treatment methods, they pose a serious challenge for modern science. The contribution of genetic factors is one of the proposed hypotheses regarding the formation of hypertrophic scars and keloids. Gene polymorphism and mutations occurring in them may interfere with the proper course of signaling pathways responsible for the subsequent stages of the wound healing process. An important role in the pathogenesis of abnormal scarring may be the TGF-B1/Smad pathway, MAPK kinase, pathway for IGF-I and its receptor, plasminogen activator inhibitor-1 and urokinase plasminogen activator, gene polymorphisms for the vitamin D receptor and the ADAM33 gene, as well as abnormal expression of suppressor genes. The effect on heat shock protein expression and type 2 hyaluronidase synthase was also shown. The explanation of the genetic basis of hypertrophic scar and keloid formation may lead to a full understanding of their pathogenesis and also have important implications in the form of therapeutic benefits resulting in the development of effective forms of treatment. keywords: keloid, hypertrophic scar, wound healing, genes