RAMIPRIL: PREFORMULATION STUDY AND FORMULATION OF IMMEDIATE RELEASE GRANULES
| Main Author: | Devi Rajni*and Kumar Sandeep |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1304289 |
Daftar Isi:
- The objective of this work was to formulate and evaluate immediate release granules of ramipril with Preformulation study for the management of hypertension. Ramipril is an angiotensin converting enzyme (ACE) inhibitor drug used for severe hypertension and myocardial infarction. The poor solubility and wettability of ramipril leads to poor dissolution. In this study physicochemical property of ramipril was improved by using solid dispersion technique. Solid dispersion of ramipril was prepared with PEG 6000 polymer at three drug: polymer ratios (1:1), (1:2) and (1:3). The Preformulation study of ramipril included melting point, FTIR study, standard calibration curves and drug polymer interaction study. The immediate release granules of ramipril were prepared by wet granulation method by using different concentrations of superdisintegrant i.e croscarmellose sodium. The solid dispersion (1:3) showed maximum solubility. The immediate release granules formulation A4 showed maximum 96. Release in 30 minutes. So SD3 and A4 were selected as the best formulations. Keywords: Ramipril, Solid dispersion, Immediate release granules, Hypertension.