ANALYSIS OF ROLE OF ANTIOXIDANTS IN DIABETIC HCV PATIENTS IN PAKISTAN
| Main Author: | Umar Sultan, Sana Urooj, Saba Bilal |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1301124 |
Daftar Isi:
- Introduction: Hepatitis C virus (HCV) is one of the main causative agents of chronic viral hepatitis. Chronic hepatitis C can progress to cirrhosis and eventually to hepatocellular carcinoma over a period of 20 to 30 years. Objectives of the study: The main objective of the study is to find the role of antioxidants in diabetic HCV patients in Pakistan. Material and methods: This study was done at DHQ teaching hospital Gujranwala, Pakistan during Oct 2017 to Dec 2017. This study was conducted according to the rules and regulations of authority. For this research purpose we selected 50 individuals of both genders. This study was carried out on 50 patients who were categorized into three groups i.e., control, HCV patients and HCV/diabetes patients. The blood was collected from a cuboital vein of patients and serum was separated within one hour ny centrifugation. Results: Our results show that antioxidants are the important biomarkers for the diagnosis of liver problems in diabetic patients. The level of SOD, CAT, GSH and MDA were decreases in diabetic HCV patients as compared to normal and simple HCV patients. The important biomarker is MDA and SOD. Conclusion: It is concluded that antioxidants levels have been related to various disease processes and play a significant role in the pathogenesis of diabetic complications. Their plasma levels are usually used as a marker of lipid peroxidation. Plasma MDA, SOD, GSH and CAT was elevated in chronic hepatitis C and liver cirrhosis patients. Key words: Hepatitis, Diabetes, HCV, Antioxidants