A REVIEW OF PULSATILE DRUG DELIVERY SYSTEM
| Main Author: | N. Shiva Krishna*, Dr. B. Jayanthi, A. Madhukar |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2018
|
| Subjects: | |
| Online Access: |
https://zenodo.org/record/1296981 |
Daftar Isi:
- Pulsatile drug delivery systems are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site.the product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. diseases where in chronopharmaceutics are promising include asthma,peptic ulcers, cardiovascular diseases, arthritis, neurological disorders and hypercholesterolemia etc. various capsular, osmotic, single and multiple unit systems that are modulated by soluble (or) erodible polymer coatings, rupturable membranes are available in market. These systems are beneficial for diseases showing chronopharmacological behavior where night time dosing is required (or) for the drugs having high first pass effect (or) having site specific absorption in GIT, (or) for drugs with high risk of toxicity (or) tolerance.these systems also improve patient compliance by decreasing dosing frequency. Keywords: Chronotherapeutics, Pulsatile Drug Release, Lag Time, Time Controlled Systems.