PROTON PUMP INHIBITOR THERAPY AS A RISK FACTOR FOR CLOSTRIDIUM DIFFICLE ASSOCIATED DIARRHEA AMONG HOSPITALIZED PATIENTS
| Main Author: | Muhammad Muneeb, Aisha Javed, Zaheer Hussain Memon, Tahir Hanif, Aatir H. Rajput, Anam Shaikh and Abid Ali. |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1287891 |
Daftar Isi:
- Background: Inhibition of gastric acid removes a defense against ingested bacteria and spores, increasing the risk of some forms of gastroenteritis. A possible link between acid suppression therapy and Clostridium difficile‐associated diarrhea (CDAD) has long been debated, however, despite the high incidence of CDAD among patients being administered Proton Pump Inhibitors (PPI) therapy for gastric acid suppression, conclusive evidence regarding a link between CDAD and PPI therapy remains unavailable. Objective: This research hopes to investigate whether gastric acid suppression by PPI therapy is a risk factor for CDAD among hospitalized patients. Methodology: This retrospective analysis comprised of a total data set of 377 in-patients (derived from the hospital records via non-probability consecutive sampling) who developed CDAD (ascertained by positive laboratory reports of assay results for C. difficile toxin and clinical correlation of diarrhea) during the course of their hospital stay. The patient records were also reviewed and all patients being administered PPI therapy were identified. Variables such as admission date, antibiotic exposure, gender, age groups, patient location (medical or surgical unit), and room type at time of admission were also noted. The data obtained was analyzed using MS. Excel 2017 and SPSS v. 21.0. Results: Among the 377 subjects with a CDAD, 206 were males and 171 were females. The mean age of the sample was 31 years and the mean hospital stay recorded (at the time of diagnosis of CDAD) was 13 days. Regarding patient location, 301 patients hailed from the medical wards (general medicine – 273 and oncology – 28) and 76 from the surgical ward. 212 (56.2%) of the subjects were administered PPI therapy during the hospital stay. Conclusion:An elevated risk of developing CDAD among hospitalized patients that underwent acid suppression via PPI therapy, was found in our study. Keywords: Proton Pump Inhibitors, Clostridium Difficile, Diarrhea and Acid Suppression.