Daftar Isi: DEVELOPMENT AND EVALUATION OF RABEPRAZOLE GASTRORETENTIVE DRUG DELIVERY SYSTEM

Main Author:	*Ramachandra M. Koli, Manojkumar S.Patil, Sandhyarani S. Kamble, Meghraj A. Patil, Shashikant P. Jokar, Bharat B. Garande
Format:	Article Journal
Bahasa:	eng
Terbitan:	, 2018
Subjects:	The present study was undertaken with an aim to design develop and evaluate floating tablet of Rabeprazole which release the drug in a sustained manner over a period of 12 hours. In this resesrch work used hydroxy propyl methyl cellulose(HPMC K15M) gas generating agent sodium bicarbonate and citric acid. The high level of HPMC K15M and citric acid favors preparation of floating tablet Rabeprazole. The tablets were prepared by direct compression techniques and evaluated thickness hardness weight variation friability floating lag time and In-vitro drug release studies indicated that the floating dosage form showed slower release as concentration of HPMC K15M increases. Formulation F1 was considered as optimized formulation which shows sastisfactory sustained drug release and remained buoyant on the surface of medium for more than 12 hrours. It can also concluded that floating drug delivery system of Rabeprazole can be successfully formulated as an approach to increase gastric residence time and thereby improving its bioavailability. Keywords: Rabeprazole Floating Drug Delivery Citric acid Buoyancy Direct compression
Online Access:	https://zenodo.org/record/1286333

Daftar Isi:

The present study was undertaken with an aim to design, develop and evaluate floating tablet of Rabeprazole, which release the drug in a sustained manner over a period of 12 hours. In this resesrch work used hydroxy propyl methyl cellulose(HPMC K15M), gas generating agent sodium bicarbonate and citric acid. The high level of HPMC K15M and citric acid favors preparation of floating tablet Rabeprazole. The tablets were prepared by direct compression techniques and evaluated thickness, hardness, weight variation, friability, floating lag time and In-vitro drug release studies indicated that the floating dosage form showed slower release as concentration of HPMC K15M increases. Formulation F1 was considered as optimized formulation which shows sastisfactory sustained drug release and remained buoyant on the surface of medium for more than 12 hrours. It can also concluded that floating drug delivery system of Rabeprazole can be successfully formulated as an approach to increase gastric residence time and thereby improving its bioavailability. Keywords: Rabeprazole, Floating Drug Delivery, Citric acid, Buoyancy, Direct compression.