EVALUATION OF ANTIULCER ACTIVITY ON VIGNA MUNGO AND MUNG BY USING ALBINO RATS
| Main Author: | Leela Kalyani Chandolu*, P. Venkateswara Rao, T. Mounika, P. Sravanthi, Y. E. Raghavendra Rao |
|---|---|
| Format: | Article Journal |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1279448 |
Daftar Isi:
- A thrombus formation in the circulatory system due to failure of haemostasis causes vascular blockage and leads to serious consequences such as myocardial or cerebral infarction. Antipltelet drugs are used to prevent formation of unwanted blood clot but their uses are associated with serious side effects. In association of efforts to develop natural products from plant origin as antiplatelet agent, Vignamungoseeds were investigated for same. The well known antiplatelet drug aspirin was taken as standard drug and activity was compared with it. Adenosine phosphate induced platelet aggregation method was used. 0.4 ml of 0.9mg/dl aspirin solution was used as standard dose. The antiplatelet activity of vignamungo was relatively high (p<0.05; ANOVA) compared to aspirin. In conclusion, these observations suggest that both 100 and 200 mg/kg body weight exert different levels of inhibitory action on platelets in vitro (secretion and platelet aggregation suppression) due to differences in concentration. Keywords: Vignamungo, Aspirin, Anti-platelet activity.