Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells
| Main Author: | Lin, Cheng |
|---|---|
| Format: | Article |
| Terbitan: |
Pensoft Publishers
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1222617 |
Daftar Isi:
- Grafting of cells in Parkinson's disease (PD) results in a prion-like infection, exhibiting a Lewy body-like pathology, caused by the recipient cells. The transmission mechanism of Lewy bodies is not completely understood. Therefore, a research idea with a novel experimental strategy is proposed to investigate the transmission mechanism of α-synuclein pathology using PD patient-derived human induced pluripotent stem cells (hiPSC) in an in vitro human cellular and molecular PD model and in vivo mouse PD model for dopaminergic neuron transplantation.