Pleckstrin Homology domain Interacting Protein (PHIP); A Target Enabling Package
| Main Authors: | Oakley B. Cox, Tobias Krojer, Patrick Collins, Octovia Monteiro, Romain Talon, Anthony Bradley, Oleg Fedorov, Jahangir Amin, Brian D. Marsden, John Spencer, Frank von Delft, Paul Brennan |
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| Format: | info dataset |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1209171 |
Daftar Isi:
- SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
- The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766].