Nephroprotective influence of ademetionine on the functional state of rats kidneys in conditions of gentamicin-induced kidney injury
| Main Authors: | Zamorskii, I. I., Drachuk, V. M. |
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| Format: | Article Journal |
| Terbitan: |
, 2018
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| Online Access: |
https://zenodo.org/record/1187159 |
Daftar Isi:
- Zamorskii I. I., Drachuk V. M. Nephroprotective influence of ademetionine on the functional state of rats kidneys in conditions of gentamicin-induced kidney injury. Journal of Education, Health and Sport. 2018;8(2):299-304. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1187159 http://ojs.ukw.edu.pl/index.php/johs/article/view/5327 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.02.2018. Revised: 05.02.2018. Accepted: 26.02.2018. "Pathological Physiology of Kidneys & Water Salt Homeostasis" February, 15-16, Odessa Materials of conference NEPHROPROTECTIVE INFLUENCE OF ADEMETIONINE ON THE FUNCTIONAL STATE OF RATS KIDNEYS IN CONDITIONS OF GENTAMICIN-INDUCED KIDNEY INJURY I. I. Zamorskii, V. M. Drachuk Higher State Educational Institution of Ukraine «Bukovinian State Medical University» Abstract Nowadays acute kidney injury (AKI) is considered as an issue of increased global concern as its incidence is increasing over the years despite introduction of new therapies. Every 5th case of AKI is a result of toxic influence, including nephrotoxic effects of drugs. Nephrotoxicity is one of the most important side effects of aminoglycoside antibiotics, especially gentamicin, which causes kidney damage of different degree in 25% of patients. For this reason, there is a constant search for new therapies with nephroprotective activity, able to prevent or decrease toxic kidney injury during treatment with aminoglycosides. Functional state of kidneys in conditions of gentamicin-induced AKI and use of ademetionine was studied in an experiment on white male rats. Nephroprotective effect of ademetionine resulted in amelioration of excretory and ion-regulating kidney function of animals, confirmed by an increase in diuresis, glomerular filtration rate (GRF), reduction in proteinuria, normalization of sodium and potassium balance. An established correlation between indices reflects restoration of functional activity of both proximal and distal parts of nephrons as well as maintenance of the kidney mechanisms of autoregulation. Obtained results justify further study of ademetionine as a promising nephroprotector. Key words: acute kidney injury, nephroprotection, ademetionine, gentamicin