Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism
| Main Authors: | Коloskova, О. К., Bilous, Т. М., Ivanova, L. A., Dikal, M. V., Kopchuk, T. G. |
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| Format: | Article |
| Terbitan: |
, 2018
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| Online Access: |
https://zenodo.org/record/1185397 |
Daftar Isi:
- Коloskova О. К., Bilous Т. М., Ivanova L. A., Dikal M. V., Kopchuk T. G. Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism. Journal of Education, Health and Sport. 2018;8(1):198-205. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.11853917 http://ojs.ukw.edu.pl/index.php/johs/article/view/5315 https://pbn.nauka.gov.pl/sedno-webapp/works/858114 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 23.01.2018. Revised: 26.01.2018. Accepted: 31.01.2018. "Pathological Physiology of Kidneys & Water Salt Homeostasis" February, 15-16, Odessa Materials of conference UDC: 616.248-053.2-085.281:575 PECULIARITIES OF BRONCHIAL ASTHMA MANAGEMENT IN CHILDREN WITH ALLELIC GSTT1, GSTM1 GENE POLYMORPHISM О. К. Коloskova, Т. М. Bilous, L. A. Ivanova, M. V. Dikal, T. G. Kopchuk Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine dikalmariana@gmail.com Abstract Content of peculiarities of basic anti-inflammatory therapy and its efficacy in children with available or absent deletion polymorphism of GSTM1 and GSTT1 genes coding II phase enzymes of GSTM1 and GSTT1 xenobiotic detoxication considering their acetylation status. It is established that in patients of a school age suffering from bronchial asthma with available deletion polymorphism of GSTT1 and GSTМ1 genes associated with slow acetylation phenotype anti-inflammatory therapy should be intensified emphasizing on much higher “step” or by means of addition of other anti-inflammatory drugs. In patients without deletion polymorphism of the examined genes in terms of quick acetylation phenotype average daily doses of iGCS have a tendency to prevailing over the similar ones in patients from the groups of comparison, and their triple administration is reliably higher. Key words: bronchial asthma, GSTT1, GSTМ1, gene polymorphism.