Changes in a functional condition of prooxidant system in guinea pigs' blood in experimental allergic alveolitis and their correction with thiotriazolin
| Main Authors: | Sadljak, Oksana Volodumurivna, Solvar, Zoryana Ljubomurivna, Baida, Mariana Ljubomurivna |
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| Format: | Article Journal |
| Terbitan: |
, 2018
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| Online Access: |
https://zenodo.org/record/1182648 |
Daftar Isi:
- Sadljak Oksana Volodumurivna, Solvar Zoryana Ljubomurivna, Baida Mariana Ljubomurivna. Changes in a functional condition of prooxidant system in guinea pigs’ blood in experimental allergic alveolitis and their correction with thiotriazolin. Journal of Education, Health and Sport. 2018;8(1):186-190. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1182648 http://ojs.ukw.edu.pl/index.php/johs/article/view/5298 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.12.2017. Revised: 15.12.2017. Accepted: 28.01.2018. changes in a functional condition of prooxidant system in guinea pigs’ blood in experimental allergic alveolitis and their correction with thiotriazolin Oksana Volodumurivna Sadljak1, Zoryana Ljubomurivna Solvar2, Mariana Ljubomurivna Baida3 Danylo Halytsky Lviv National Medical University 1 Department of pathological physiology, PhD, Associate Professor 2 Department of pathological physiology, postgraduate student 3 Department of pathological physiology, PhD, Assistant Professor Lviv, Ukraine Abstract The study shows that significant elevation of conjugated dienes and malondialdehude in the blood of guinea pigs depend on experimental allergic alveolitis duration was detected. Oxidative stress can arises from overproduction of reactive oxygen species(ROS) by metabolic reactions that use oxygen. ROS also affects the expression of several genes by upregulation of redox-sensitive transcription factors. Regulation of redox state is critical for cell viability, activation, proliferation, and organ function. Corrective effect of thiotriazoline on these indicators have demonstrated . Key words: experimental allergic alveolitis, malondialdehude, conjugated diens, thiotriazolin.