A REVIEW ON SOLID DISPERSIONS MECHANISM OF SOLUBILITY IMPROVEMENT AND CHARACTERIZATION
| Main Author: | Dr. M. V. Nagabhushanam 1, Radhika Padarthy 2* |
|---|---|
| Format: | Article |
| Terbitan: |
, 2015
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1165216 |
Daftar Isi:
- ABSTRACT As an increasing proportion of drugs undergoing development are poorly water-soluble, solubilization technologies have become an essential feature in bringing them successfully to market. The solid dispersion is one such technology which in recent years has led to the approval of a large number of products, suggesting it is now the preferred technology for drug solubilization. However, despite considerable progress in understanding the nature of solid dispersions, many aspects of their behavior remain to be clarified such as the kinetics of phase separation in the solid state and in solution, and even such simple questions as how polymer molecular weight affects the drug crystallization rate. Research is also needed into the use of solid dispersions in conjunction with controlled release technologies such as the osmotic pump. KEYWORDS: Solubilization Technologies, Solid Dispersion, Controlled Release etc.,