Figure 4. Simulation (Monte-Carlo, n=200) results elderly patients taking a 10mg oral dose resulting in similar Cmax, maximum plasma concentration, to the young patients taking a 40mg oral dose. The dotted lines illustrate the 10th and 90th percentiles of plasma levels of the elderly population with a 10mg oral administration of propranolol.-The Brain and Propranolol Pharmacokinetics in the Elderly
| Main Authors: | Andy R. Eugene, Wayne T. Nicholson |
|---|---|
| Format: | info Image |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://www.edusoft.ro/brain/index.php/brain/issue/view/30 |
Daftar Isi:
- Thus, the package insert (see 1) recommends clinicians start at the lower end of the dosing range, without further details. Similarly, Pfizer manufactures Inderal® LA (Propranolol HCI), which is the long-acting form of propranolol and their package insert (see 2) states, “There is no information available for elderly patients.” Though the kinetics for the long-acting formdiffers from the standard form, manufactured by Wyeth, we would suspect a 10mg dose for the elderly would achieve a similar maximum plasma concentration (Cmax) to that of the younger patient cohort.This 10mg, which is 25% of the original 40mg, dosing schedule is based on our simulations at 10mg in the geriatric population.