A CASE OF RHUEMATOID ARTHRITIS ASSOCIATED WITH CONSTRICTIVE PERICARDITIS
| Main Authors: | Sherif A. Nasef, Ali M. AlMuslim, Amer S. Zahralliyali, Hisham S. AlMomen, Alsir G. Ali. |
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| Format: | Article |
| Terbitan: |
, 2017
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/1155222 |
Daftar Isi:
- RA is a progressive inflammatory autoimmune disease with articular and systemic effects. Its exact cause is unknown, but genetic and environmental factors are contributory. T cells, B cells and the orchestrated interaction of pro-inflammatory cytokines play key roles in the pathophysiology of RA. The release of cytokines, especially TNF-α, IL-6 and IL-1, causes synovial inflammation. In addition to their articular effects, pro-inflammatory cytokines promote the development of systemic effects, including production of acute-phase proteins (such as CRP), anaemia of chronic disease, cardiovascular disease and osteoporosis and affect the hypothalamic?pituitary?adrenal axis, resulting in fatigue and depression.