Preliminary Study On Latent Membrane Protein-1 (LMP-1) And Bcl-2 Associated X (BAX) In Exosomes Of Patients With Nasopharingeal Cancer In NTB Provincial Hospital
| Main Authors: | Angrayany Sapar, Puput, Kadriyan, Hamsu , Yudhanto, Didit |
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| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Rifa'Institute
, 2021
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| Subjects: | |
| Online Access: |
https://kesans.rifainstitute.com/index.php/kesans/article/view/9 https://kesans.rifainstitute.com/index.php/kesans/article/view/9/12 |
Daftar Isi:
- Nasopharyngeal cancer is one of the most common types of cancer in Indonesia, especially head and neck cancer. One of the etiology of this cancer is infection with Epstein-Barr virus. Early diagnosis is difficult to establish because the early signs and symptoms of nasopharyngeal carcinoma are not specific. Examination of latent membrane protein-1 (LMP1) oncogene expression and BCL2-associated X (BAX) gene expression proved to be useful in the identification of nasopharyngeal cancer. LMP1 oncogene is an oncogene that functions as a tumor necrosis factor receptor (TNFR), so that apoptosis does not occur and promotes invasion and metastasis. The BAX gene is a pro-apoptotic gene that inhibits cancer development, but its regulation will be downregulated by LMP1 because LMP can protect B-cells from apoptosis.